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Most states require BMI of 27+ with at least one weight-related comorbidity (hypertension, dyslipidemia, sleep apnea, NAFLD) or BMI of 30+ without comorbidities

2) Engagement is linked to longer medication program persistence and stronger renewal In a separate January 2026 analysis focused on persistence, members in the top quartile of engagement were, on average, on a GLP-1 medication program for over twice as long (2.2x) within the first 12 months as those in the bottom quartile

There was a negative correlation between TXNIP and insulin (Fig

le Roux was a previous investor in Keyron, which develops endoscopically implantable medical devices intended to mimic the surgical procedures of sleeve gastrectomy and gastric bypass

Cat#76-0002 & Cat#76-0702) and STARTLE software module (PACKWIN-CSST, PACKWIN version 2.0