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Nat Rev Rheumatol 18 , 311325 (2022)
"We believe maintaining the glutathione-to-iron ratio is very important, because if you have too little glutathione, then iron becomes very reactive, and if you have too much glutathione, the iron will not be usable." Their experiments determined that SLC25A39 carries a unique iron signature on its surface as part of the glutathione sensing mechanism
Loading regimens involve 1 mg three times weekly for two weeks, or alternate-day dosing if neurological symptoms are present
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