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In the case of GLP-1, achieving higher bias for binding to areas of the receptor that favors downstream cAMP pathway vs -arrestin pathway could be one
GLP-1 Receptor Agonists More and more clinicians are using GLP-1s off-label in people with type 1 diabetes, particularly in those who also have obesity or high insulin requirements, says Mihail Zilbermint, MD, an associate professor of medicine at Johns Hopkins University School of Medicine and the chief of the division of endocrinology, diabetes, and metabolism at Suburban Hospital in Maryland
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We next compared microglia gene expression changes using pseudobulk analysis, comparing de- and remyelination microglia to their respective baseline controls (Supplementary Data 9)
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