glp 1 fgf21 agonist boehringer A peptide triple of GLP-1, neuropeptide Y1, and neuropeptide Y2 receptors promotes glycemic control and weight loss Safety and efficacy of GLP-1/FGF21

Potential advantages Generally simpler anatomy than gastric bypass No intestinal rerouting Strong option for many first-time bariatric surgery patients Can be a good fit for patients who want a restrictive/metabolic procedure Usually avoids the malabsorption component of bypass Important considerations May worsen or trigger acid reflux in some patients May not be the best option for severe GERD or Barretts esophagus Requires lifelong attention to portion size, protein, vitamins, and habits Some patients may need revision later if reflux or weight regain occurs Gastric Bypass Also called Roux-en-Y gastric bypass Gastric bypass creates a small stomach pouch and reroutes part of the small intestine

10.1038/s41418-019-0488-1 14 DasI.TuominenR.HelledayT.HanssonJ.Warpman BerglundU.Egyhazi BrageS

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