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By stabilizing TDP-43 and facilitating its degradation, these chaperones attenuate its toxic gain-of-function effects

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DPP4 in Inflammatory Bowel Disease Inflammatory bowel disease (IBD), including Crohns disease (CD) and ulcerative colitis (UC), is a common autoimmune-mediated digestive tract disease

The pathophysiological basis for dumping syndrome treatments is summarized in Fig

The exchange of glycine for alanine at the 15th position, which is speculated to enhance bioactivity