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Common signs include: Fatigue and weakness Numbness or tingling in the hands and feet Difficulty walking or balance problems Mood changes, such as depression or anxiety Cognitive difficulties, including memory loss or confusion If not treated, a B12 deficiency can cause serious problems

Local anesthetics structure-dependently interact with anionic phospholipid membranes to modify the fluidity

Neurology, 41 (11), 1726-1732

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In these cases, patients pay out of pocket