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The orange dots indicate known ER-annotated proteins curated from databases described in Supplementary Tables 1, 2
HDAC inhibition can lead to transcriptional activation of several key tumor-related genes such as p21WAF1/CIP1, P53, GATA-1 and -estrogen receptor, which help to inhibit cancer proliferation and induce differentiation (Victoria et al., 2000)
doi:10.1007/s13555-022-077759-1 5
Skaper 2012, 2018)
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