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Together they provide coverage of the primary cellular mechanisms investigated in ageing research

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This reduced output means skin loses structural support progressively, with wrinkles forming where the weakened matrix can no longer maintain smooth surface topology

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The peptides under investigation, include: Nle-AngIV (Nle-Tyr-Ile-His-Pro-Phe) and its analogs such as D-Nle-YIH, acetyl-NleYIH, -amino butyric acid-YIH, NleYI-amide, and the primary focus, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide (Dihexa)

10.1016/j.biomaterials.2016.04.018 Biomaterials 12 JeonO