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Consuming foods or beverages with caffeine could potentially increase spironolactones effects on clearing water and salt from the body

Some supplements also contain phyto-oestrogenic compounds (e.g., soy isoflavones, red clover), which could theoretically influence oestrogen-sensitive tissue, though evidence for clinical harm in endometriosis remains limited

Researchers suspect that by altering how the brain processes these rewards, the medications might reduce the fundamental desire to drink