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For the [U 13 C]glutamine isotopic tracing analyses (Fig 2E), MYC liver tumors were generated through hydrodynamic transfection of 8weekold FVB/n male mice (Taconic Biosciences) (Fig EV3), as described previously 28

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16 Additionally, long-term management of patients with tumors, including breast cancer, is crucial as it directly impacts patients quality of life and survival time

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