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Rumbel Professor for Healthy Aging Research Oregon State University Copyright 2002-2026 Linus Pauling Institute Figure Alternative Text Figure 1

How IGF1 LR3 Works: Stimulates muscle cell proliferation and differentiation Activates satellite cells , leading to muscle repair and growth Increases glucose and amino acid uptake into muscle tissue Enhances protein synthesis and reduces muscle breakdown (catabolism) Promotes neuroregeneration and cellular recovery IGF1 mediates many of the growth-promoting effects of growth hormone and has potent anabolic effects on skeletal muscle. Florini et al., Annual Review of Physiology IGF1 is naturally stimulated by growth hormone via the liver

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The answer depends on what you are trying to fix

CagriSema looks more familiar and potentially easier to contextualize because it builds on semaglutide plus amylin

For individuals using GLP-1 receptor agonists, appetite changes and smaller meal volumes can make nutrition consistency harder to sustain over time