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Her goals go beyond the scale
For some patients, weight regain despite intensive lifestyle efforts may warrant consideration of resuming tirzepatide or transitioning to alternative anti-obesity medications, provided they meet FDA-indicated criteria (BMI 30 kg/m or 27 kg/m with weight-related comorbidity)
Weight loss from GLP-1 medications does not distinguish between fat and muscle
Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide
What caught my attention is that muscle volume and muscle function are being assessed from this early stage
In the Phase 2 trial protocol, participants reached the 12mg maximum dose at week 20 after five escalation steps (1mg, 2mg, 4mg, 8mg, 12mg), each held for four weeks
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