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Its main job
Who Are the Best Candidates for Weight Loss Treatments
In the case of liraglutide, the SCALE trial was used as the reference for percentage total body weight lost, in preference to the LEADER cardiovascular outcome trial
found that T1 stimulated endothelial cell migration and angiogenesis in vitro and accelerated wound healing (including reepithelialization and collagen deposition) in an animal punch-wound model (Malinda et al., J Immunol 160(2):1001-1006)
It just needs the right building blocks
GLP-1RAs directly stimulate POMC/CART neurons and indirectly inhibit NPY and AgRP to increase measures of satiety and decrease hunger, resulting in reduced energy intake, thereby facilitating weight loss (Figure 6)
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