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Cognitive disorders Pre-clinical and mechanistic studies Our search retrieved a high number ( N = 189) of pre-clinical or mechanistic studies assessing the possible effects of GLP-1RAs on cognitive disorders, which cannot be described in the main text of this article due to space constraints (Supplementary Section 4)

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Patients were then randomized to one of two treatment sequences: 1) VYVANSE (optimized dose) followed by placebo, each for one week, or 2) placebo followed by VYVANSE, each for one week