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Eli Lilly reported these results in mid-2025, and the retatrutide availability timeline now points toward potential FDA approval no earlier than 2027, as additional phase 3 trials continue

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consistent with the findings of a similar study, our results revealed that PFOS induced a concentration-dependent reduction in mitochondrial bioenergenesis, demonstrating that the administration of PFOA and PFOS (50200 M) induced the production of ROS, dissipation of mitochondria membrane potential, and apoptosis of HepG2 cells 31