For both compounds, avoid repeated freeze-thaw cycles and minimize exposure to ambient air during sampling
Supplementation of B12 for a number of weeks prior to supplementing methylfolate, will avoid reactions to methylfolate
The proposed mechanism begins with reduced NNMT activity but extends into several interconnected pathways
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It declines with age, and lower NAD+ is associated with slower metabolism and the changes we lump together as getting older. NNMT, meanwhile, consumes the raw materials your body uses to make NAD+ and in fat tissue, NNMT is often overexpressed, which can drag NAD+ down right where you least want a sluggish metabolism
Tracking these markers at baseline, mid-cycle (week 46), and post-cycle (week 812) provides the clearest picture of metabolic shifts attributable to the stack