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ShHTL4 and ShHTL7 were able to hydrolyze both rac -GR24 and 5DS, consistent with a previous report 28 in which YLG was used to measure their enzymatic activity and their responsiveness to rac -GR24 and 5DS in cross-species complementary assays 13,29

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These insights support more informed provider conversations about personalized dosing and expected response timelines

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