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Then on the molecular level, our team recently showed, in collaboration with Dr Marisa Roberto from Scripps in La Jolla, California, that semaglutide may in fact change the GABA transmission at the level of some brain regions, such as the amygdala and the prefrontal cortex

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Axonal projection patterns of NTS Gcg neurons A previous immunohistochemical study using custom-made GLP-1 monoclonal antibodies examined the distribution of GLP-1 expressing nerve terminals in the rat forebrain regions [7], but provided limited information about the overall GLP-1 neuronal projections in the mouse brain

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If the desired results are not seen after 3-6 months, or if the patient cannot tolerate the medication, discontinuation or alternative treatments may be considered

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Human thyroid C-cells have very few GLP-1 receptors, and large clinical trials have not shown an increased risk compared to placebo

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