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Caffeine , due to its vasocontrictive properties, is sometimes combined with aspirin and/or acetaminophen as well (Aukerman 2002)

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In mice and rats treated with acetaminophen at doses within the clinical dosing range, cumulative adverse effects on reproductive capacity were reported

Rotate injection sites systematically, moving at least 1 inch from previous injection points

For use in prophylaxis of migraine headaches: Valproic acid is contraindicated in women who are pregnant and in women of childbearing potential who are not using effective contraception [seeWarnings and Precautions (5.2, 5.3, 5.4) and Use in Specific Populations (8.1)]

Report any adverse effects to healthcare provider promptly