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GLP-1 receptor agonists mimic the action of naturally occurring hormones that regulate blood glucose and appetite by: Slowing gastric emptying, promoting feelings of fullness Reducing appetite signals in the brains hunger centers Improving insulin secretion while suppressing glucagon release Creating a caloric deficit through reduced food intake Originally developed for type 2 diabetes management, these medications have gained FDA approval for chronic weight management in adults with obesity or overweight with weight-related comorbidities

*Over a 72-week period, individuals who took tirzepatide once a week saw an average reduction in body weight of 15%

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This increase in energy levels can motivate individuals to engage in regular physical activity, which is a critical component of any weight loss regimen

GLP- 1 Receptor Signaling The heterotrimeric G proteins are known to mediate signaling through the canonical GLP- 1 receptor