As a doctor, theres a lot of burden on your shoulders when you are prescribing something with insufficient evidence, but the patients insist on giving it a try. With no formal approvals surrounding their use from regulatory bodies like the Drugs Controller General of India (DCGI), they are considered off-label treatments
Keep refrigerated and shake well before use
Michael Greger, Chief Science Officer at NutritionFacts.org, When selecting a B12 supplement, its important to focus on bioavailability
It is known to help support the detoxification of environmental pollutants, heavy metals, and other toxins
A study using a migraine rat model revealed that alterations in mitochondrial dynamics inhibit mitochondrial biosynthetic signaling in trigeminal ganglion neurons (70)
Using co-immunoprecipitation (CO-IP), the study confirmed that FOXO4-DRI prevents FOXO4 binding to p53, facilitating phosphorylated p53 nuclear exclusion, which triggers BAX upregulation and cleaved caspase-3 activation driving selective apoptosis of senescent endothelial cells