hfpef semaglutide STEP-HFpEF Trial Weight Loss Drug Works Against

High-fat diet changes the temporal profile of GLP-1 receptor-mediated hypophagia in rats

Mark AL, Sun Z, Warren DS, Lonze BE, Knabel MK, Melville Williams GM, et al

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Transferring conclusions from one to the other requires explicit extrapolation that most commercial claims do not acknowledge making

Adverse events were reported by 79% of participants receiving semaglutide and 82% receiving placebo

Theres a noticeable lack of comprehensive, long-term studies for both semaglutide and tirzepatide, making it harder to assess their prolonged efficacy and safety