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The demonstration of cardiorenal benefits with SGLT2i in clinical trials both for participants with CKD and type 2 diabetes and for those without [23,24,25] and the updated 2022 KDIGO guidelines recommending SGLT2i as first-line therapy for patients with CKD and type 2 diabetes regardless of glycemic control [6] have likely driven a shift toward their broader use for preventive cardiorenal protection and earlier implementation for patients with type 2 diabetes

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Individual responses vary, but some individuals may experience improvements in energy levels and symptoms within a few days after starting B12 injections.

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Abstracts from the 2022 American Diabetes Association Meeting