Research into the efficacy of GLP-1 drugs found that, in a clinical trial setting, Semaglutide (Ozempic and Wegovy) could result in a 14.9% reduction in body weight over the course of 68 weeks
Signaling Mechanism for Modulation by GLP-1 and Exendin-4 of GABA Receptors on Rat Retinal Ganglion Cells
The latter effect, intended to prolong feelings of fullness and reduce food intake, can inadvertently increase the risk of heartburn
Connective tissue disorders such as Ehlers-Danlos syndrome also make skin and vessels more fragile, producing easy bruising and hyperflexible joints

1040 Contribution of patient-reported versus clinician-reported outcomes to core domain sets and differences in expert and patient voting patterns across these domains Zachary Hopkins 1 , Dallin Ringwood 2 , Meg Takara 2 , Zachary Frost 3 , Mark Conley 4 , Aaron Secrest 5 , Jacob Kean 5 1 University of Utah Health, Salt Lake City, Utah, USA, 2 University of Utah School of Medicine, Salt Lake City, Utah, USA, 3 Noordt College of Osteopathic Medicine, Provo, Utah, USA, 4 University of North Texas Health Sciences Center, Fort Worth, Texas, USA, 5 University of Utah, Salt Lake City, Utah, USA Journal of Patient-Reported Outcomes 2026 , 10(Suppl 1) :1040 Aims Core outcome domain sets define and help to establish critical concepts for clinical research and/or practice and include patient-reported outcome (PRO)- and clinician-reported outcome (CRO)-based concepts
True weight loss is about more than just shedding pounds