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GLP-1 inhibits glucagon release by regulating -cell N- and L-type Ca2+ channel-dependent cytokinesis (De Marinis et al., 2010)

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While they share a broad overarching topologycharacterized by a large, highly structured extracellular domain (ECD) connected to a seven-transmembrane (7TM) helical bundletheir specific orthosteric binding clefts and the flexible extracellular loops that govern ligand entry are distinctly evolved to recognize only their cognate native hormones

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