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More recently, a comprehensive 2025 systematic review published by The ME Association evaluated the efficacy of various dietary supplements for ME/CFS
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68 The widespread use of GLP-1RAs has raised concerns about their safety profile
Topical products are ideal for people who have trouble taking supplements orally, such as those with digestive issues
On top of that, common gastrointestinal side effects like nausea or vomiting especially when starting GLP-1 therapy can further disrupt how well the contraceptive hormones are absorbed
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