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Complications of radiation therapy (e.g., radiation necrosis)
It is converted by the body into Adenosylcobalamin and Methylcobalamin so they can be absorbed
TS inhibition by 5FU regulates mitochondrial biogenesis through mTORPGC1 signalling 5FU has a multimodal mechanism of action: promoting DNA damage directly via its metabolite FdUTP or by inhibition of TS via FdUMP, depleting the pool of thymidine available for DNA synthesis, and causing RNA damage via FUTP (Fig
This is similar to how high blood pressure or diabetes medications work if the medication is treating a chronic condition, stopping it typically reverses the benefit
JES contributed to the design of the study, acquisition and interpretation of the data, and revision of the manuscript
John Horton: A couple other things that come up I've seen is Ozempic teeth. That can't be from rapid weight loss, I'm guessing, because there's not a lot on the teeth
