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10.1016/s0009-8981(03)00200-6 Clin Chim Acta

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1 Irregular heartbeats Across Phase 2 and Phase 3 trials, irregular heartbeats were reported in 2 to 11% of people on retatrutide, compared with around 2% on placebo

Current evidence, including magnetic resonance imaging studies, suggests that skeletal muscle alterations resulting from GLP-1 RA-induced weight loss, such as enhanced insulin sensitivity and reduced muscle fat infiltration, are adaptive, thereby improving muscle quality despite concurrent reductions in lean mass [112]