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Lifestyle interventions were the least effective treatment, the investigators found, producing a mean total body weight loss of 7.4% at the end of the treatment period, followed by a mean per-month weight regain of 0.14%, with participants reaching their pre-intervention weights within 4.1 years

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91 Similarly, a weight-matched randomized controlled trial in metabolic dysfunctionassociated steatotic liver disease found that GLP-1R agonist therapy produced additional improvements in DNL and lipid profiles compared with equivalent lifestyle-induced weight loss, providing evidence that some of these effects operate independently of fat mass reduction

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