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Follow-up of 57 patients from five to 41 years and a profile of 14 patients with permanent severe visual loss

Diabetes - GLP-1 agonists should be primarily considered in patients with type 2 diabetes with suboptimal glycaemic control despite maximal tolerated dose of metformin (+/- other agents) especially where weight loss is desired and/or significant stroke risk is present

In a meta-analysis of cardiovascular outcomes of SGLT2 inhibitors, the relative risk reduction of MACE was 11 percent with an NNT (Number Needed to Treat) of 97 over 3.3 years [15] (GLP-1-RA 12% and NNT=75 over 3.2 years) [13]

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