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The resulting clusters aligned to defined tissue regions, including the urinary bladder muscle (cluster 2), adventitial layer (cluster 5) and urothelium (cluster 6) (Fig

PLC generates inositol trisphosphate (IP 3 ) and diacylglycerol (DAG), which mobilize intracellular calcium and activate protein kinase C

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Second, an in vitro chromosome aberration assay was performed in Chinese Hamster Ovary (CHO) cells treated with AOD9604 (20, 50, 100, 200 g/mL) in the absence or presence of an S-9 metabolic activation system