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Another problem with targeted therapy of signaling pathways is that these therapeutics should be designed to act locally
Brain Res Rev 56:183197 Cagnon L, Braissant O (2008) Role of caspases, calpain and cdk5 in ammonia-induced cell death in developing brain cells
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Conversely, when glutamine is scarce, nave CD4+ T cells become invigorated and morph into Foxp3+ Treg cells (111)
One acts narrowly at MC1R, the other broadly across the melanocortin receptor family
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