A study conducted at the University of Texas Southwestern Medical Center found that NNMT inhibition in obese mice reduced body weight by 7% over four weeks without changes in food intakea reduction driven entirely by increased energy expenditure
Without intrinsic factor, B12 would not be able to be absorbed
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AOD-9604 is a synthetic 16-amino-acid peptide corresponding to the C-terminal lipolytic fragment of human growth hormone (residues 177191), with an N-terminal tyrosine added for stability
Importantly, these body weight changes were not attributable to differences in food intake across the groups, as all treatments showed similar food consumption patterns in both lean and obese mice
7 Researchers from the 2020 study also noted that the increase in vitamin B12 was likely unrelated to typical dietary intake or standard supplementation because food and supplements generally do not substantially affect plasma B12 concentrations