Liraglutide is indicated as an adjunct to a reduced-energy diet and increased physical activity for weight loss management in adults with a BMI 30 kg/m 2 or BMI of 27 kg/m 2 and at least one weight-related comorbidity, including type 2 diabetes mellitus, hypertension, dyslipidaemia, or obstructive sleep apnoea
Lancet Diabetes Endocrinol 2021;9:743-54.ArticlePubMed 59
Overwhelming reactive oxygen species lead to increased, accumulated damaged cells in the form of oxidative stress
If this process is disrupted, a deficiency can occur even with a B12-rich diet
This includes, but is not limited to, injections into joints, bursa, or the epidural space , which are all routes of administration that were previously allowed
Larger, multicenter trials with balanced cohorts and extended follow-up are required to confirm comparative effects on HbA1c sustainability, beta-cell preservation, and insulin sensitivity