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doi: 10.1038/s41392-023-01481-w 104 WishartDSFeunangYDMarcuAGuoACLiangKVzquez-FresnoRet al

It has not been evaluated by bodies like the United States Food and Drug Administration (FDA) or comparable international agencies, leading to a significant gap in understanding its safety for human use

This result also indicates that GPx activity can be used as a marker of Se when animals are deficient in Se, and when the maximum requirement of Se is exceeded, GPx activity cannot reflect tissue Se levels

Second, metabolic enzyme inhibitors, which are the COX-2 inhibitor nonsteroidal anti-inflammatory drugs used in clinical trials to treat patients with GA, can target specific AA metabolic pathways as well as alleviate inflammation during acute GA episodes

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