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In the case of GSAO, a reversible renal toxicity described in preclinical studies at the maximal tolerated dose was not observed in human during clinical Phase I (Horsley et al., 2013)
REWIND differed by enrolling a lower-risk population: 9901 patients, two-thirds without prior cardiovascular events, randomized to dulaglutide 1.5 mg weekly versus placebo for a median of 5.4 years
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Hattori S
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