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Alterations in neuroimmune signaling have previously been overlooked but have recently gained more attention and demand for further investigation [159]

The physician should provide information to the patient about the signs and symptoms of hepatotoxiciy that should cause alarm (e.g., nausea, fatigue, lethargy, pruritus, jaundice, right upper quadrant tenderness and "flu-like" symptoms)

For peripheral nerve analysis, a 5-mm-long piece of tail 15 mm distal from the tail base was collected from each sacrificed animal, fixed in 4% formaldehyde in phosphate buffer (pH 7.4), decalcinated, and impregnated with 1% osmium tetroxide for a few days

Anfossi, L., Di Nardo, F., Giovannoli, C., Passini, C

Without it, fatigue, mood changes, and even nerve problems can set in