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Too much signal and you waste money without additional benefit, the response curve plateaus rather than climbing indefinitely

Discontinuation rates due to adverse effects were also higher with retatrutide being 16-17% compared with 2% with dulaglutide and 0-4% with placebo

Especially our stress levels

Higher rates of persistence and adherence in patients with type 2 diabetes initiating once-weekly vs daily injectable glucagon-like peptide-1 receptor agonists in US clinical practice (STAY study)

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The honest answer is that oral BPC-157 probably delivers less systemic peptide than equivalent injectable doses