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Brain injury causes cognitive impairment, increases the accumulation of amyloid precursor protein (APP), extracellular beta amyloid (A) peptide and intracellular neurofibrillary tangles (NFTs) consisting of tau protein associated with inflammatory cytokine release (Johnson et al., 2012
Additionally, it is proposed that the maternal antioxidant mechanisms may be inadequate to compensate for the antioxidant deficiencies induced by the developing T21 fetus (Buczyska et al
doi: 10.1016/j.molcel.2022.03.022 117 JiangXStockwellBRConradM
The biosynthetic mechanisms for synthetases use energy from nucleoside triphosphates, whereas synthases do not
however early hepatic changes that occur in these infants remain unclear
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