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As a GLP-1 receptor agonist, it works by mimicking a natural hormone that targets the areas of the brain that regulate appetite and food intake
however, this program was discontinued in April 2025 following a potential drug-induced liver injury signal and earlier tolerability concerns, leaving orforglipron as the leading oral small-molecule GLP-1RA in late-stage development
Southern Medical Association
Many existing programs dont account for the full scope of variables that contribute to weight loss, including diet, exercise, metabolism, comorbid conditions, genetics, and mental health
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