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These cytokines also contribute to IR through mechanisms including inhibitory phosphorylation of insulin receptor substrate-1 (IRS-1) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) pathway, while also promoting glucocorticoid resistance and HPA axis hyperactivity [80]

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Medicare Part D claims for Ozempic, Rybelsus, Trulicity, and Mounjaro increased from 1.4 million in 2018 to 8.7 million in 2022 (Figure 1)

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