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The sNDA was based on results from the Phase 3, double-blind, parallel-group, placebo-controlled cardiovascular outcomes trial, SOUL. The trial reported a 14% reduction in the risk of MACE compared to placebo when added to standard of care in patients with T2DM and established CVD and/or CKD

Nodes within the comorbidity network that were disconnected (i.e., lacking edges or connections to other nodes) were not initially assigned a score, as centrality metrics depend on network connectivity

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The rapid degradation of GLP-1 in humans is primarily since the alanine in position 8 is readily recognized and cleaved by dipeptidyl peptidase (DPP-4)

All of these situations are common when starting semaglutide

Ozempic is only licensed in the UK to treat type 2 diabetes, but you can buy it under the brand name Wegovy