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If a vial does accidentally freeze, it should be discarded, as freezing can degrade the peptide

This product is intended strictly for in vitro research, preclinical investigation, and analytical characterization by qualified researchers

N Engl J Med 320(9):599 Sanders ME, Akkermans LM, Haller D, Hammerman C, Heimbach J, Hrmannsperger G, Huys G, Levy DD, Lutgendorff F, Mack D, Phothirath P, Solano-Aguilar G, Vaughan E (2010) Safety assessment of probiotics for human use

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The proposed mechanism is that in the absence of efficient GST-mediated conjugation, SFN is cleared more slowly, allowing it to circulate in its active form for a longer duration and potentially exert stronger biological effects (57)

There is no side effects