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J., 3rd, et al

Until recently, however, cost remained a major barrier

REDEFINE 1, in adults with overweight or obesity without diabetes, reported 22.7% mean weight loss for the combination at 68 weeks on the on-treatment analysis, with 60% of combination participants reaching at least 20% loss and 23% reaching at least 30% (Aronne et al., 2025)

Arteriosclerosis, Thrombosis, and Vascular Biology, 41 (3)

A patient may tolerate the first few weeks well and then run into trouble later as intake changes, dose increases, or activity increases

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie , 57 (3-4), 145155