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Furthermore, CD4+ and CD8+ T cells in the TME often exhibit functional impairment, inactivation, or exhaustion, and frequently co-express multiple immune checkpoint molecules, such as PD-1, lymphocyte activation gene 3, and T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3)

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7,12,23 At the same time, not all propagation-like phenomena are mechanistically equivalent

As of February 2026, both compounds have been reclassified as Category 1 peptides, meaning they may be compounded by licensed compounding pharmacies under a physician prescription