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No appreciable changes in BMD at the hip or lumbar spine have been noted, despite the fact that a year of infliximab therapy causes a decrease in bone resorption indicators (C-terminal cross-linked telopeptide of type I collagen, CTX-1) and an increase in bone formation markers (88)
Even if a therapy option works, responsiveness drops with time
Clin Chim Acta 308:5557 Ryan S, Bacon H, Endenburg N, Hazel S, Jouppi R, Lee N, Seksel K, Takashima G (2019) WSAVA animal welfare guidelines
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Instead, it is active within mitochondrial functions