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Pneumologie 66, 470475

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The poly(L-methionine) component reduces intracellular ROS levels in macrophages by 63.8%, leading to a 31.1% reduction in M2-polarized macrophages, while R848 release activates the MYD88/IRAK1/NF-B pathway to drive M1 reprogramming, increasing the M1 macrophage population by 1.4-fold

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Further into the cascade, H2O2, a common reactive oxygen species, activates the small GTPase Ral