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128 Notably, inhibiting lactylation at K215 and K224 on canopy FGF signaling regulator 3 (CNPY3), a key regulator of protein folding in the endoplasmic reticulum, compromises the formation of the CNPY3 complex with auxiliary molecular chaperones for protein folding and lysosomal transport, thereby affecting its cellular localization and promoting lysosome rupture and pyroptosis in prostate cancer cells
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