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In osteoblasts, ferroptosis is prevented by the Nrf2/heme oxygenase 1 (HO-1) pathway via activating HO-1, which upregulates GPX4 through regulation of antioxidant-responsive elements (ARE)- dependent genes (14, 15)
Biological preventive and therapeutic experiments were conducted, where laboratory rats were divided into 6 groups, the first group G1 (positive control group), the second group G2 (negative control group), the third group G3 preventive experiment 1 (group glutathione extracted from spinach + CCl4), the fourth group G4 therapeutic experiment 1 (Group CCl4+ Glutathione extracted from spinach), the fifth group G5 Preventive experiment 2 (Group of synthetic glutathione + CCl4), the sixth group G6 therapeutic experiment 2 (Group CCl4+ Glutathione extracted from spinach)
The peptide works by dramatically increasing blood vessel formation in injured areas, essentially creating new highways for nutrients and oxygen to reach damaged tissues
Statistical analysis Treatment and data analyses were blinded by masking sample labels
Cell 39 , 724735
Initial dose: 2.5mg, which may be gradually increased to 5mg, 7.5mg, 10mg, 12.5mg, or 15mg
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