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For instance, a high acetyl-CoA/CoA ratio in the mitochondrial matrix inhibits pyruvate dehydrogenase (PDH) that catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA (Pietrocola et al., 2015)

However, it is important to collaborate with healthcare professionals to determine the appropriateness of tirzepatide and to develop a holistic approach that includes lifestyle modifications

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